If you are going to use capitals than get ones that can drain antimatter and shut down ablities. For the TEC that would be the Dunov.
Yes I used that tactic against a regenerating level 10 Titan in a game last week, I think it was a Vesari one. That Titan was simply impossible to destroy once it activated its drain ability, which happened to drain antimatter from all my ships and restored its own antimatter to about 1000. I tried to defeat it with small ships, big ships, until I tried a fleet with about 8 Dunov capital ships, all at level 4 or higher. And I had to be careful too, I had to disable the autocast on the shield restore first, otherwise the Dunovs would just waste their own antimatter on restoring the shields of small ships... and if I let that happen then the Titan would do the opposite to me, it would continuously drain the antimatter of my Dunovs, rendering them useless...
Anyway that wasn't necessary against the Tec Titan, although I suppose it would've been better to have included a few Dunovs because it would've sped up the process of destroying the Titan - it took pretty long to destroy it with just my fleet.
Get like 50+ squadrons and watch that nice Titan drop like a fly.
I had carriers and many bomber squadrons, but the bombers weren't really necessary to finish the Titan. The carriers also dropped many small missile towers, which had a really long range and were pretty powerful. I mainly used fighters (about 50 squadrons) to clear the skies in the enemy gravity well so that the AI wouldn't be able to bomb my ships. After a while, when most enemy bombers (and hangars) were destroyed I would turn a bunch of my squadrons into bombers squadrons, but they just flew around killing some turrets, I didn't really need them to destroy the Titan.
I suppose this kind of strategy only works against an AI. A human player would just select all his bombers and ships and take out my capital ships one by one, then my Titan, leaving me empty-handed. I wouldn't know how to win against such tactics, fortunately the AI isn't that smart.