A long time ago, the fleet wiping ability combo was [(Animosity+Vengeance)+Ruthlessness+Cleansing Brilliance+(Illuminators+Amplify Energy Aura)]+Malice. If you combined all those abilities properly, you would end up with preposterously high damage to enemy fleets.
Animosity+Vengeance: while it would have to be used just before casting Malice because it would be overwritten, but it effectively took double the enemy fleet's power and used it against it.
Ruthlessness: increased DPS by 1, but when propagated across the entire fleet, that suddenly became a very fearsome ability.
Cleansing Brilliance: a properly lined up shot can hit multiple targets which will all take full damage from the shot, each one taking 2000 raw damage.
Illuminators [Damage Bug]+Amplify Energy Aura: during primary combat, this would and still is a significant portion of your damage output. Just before casting abilities, you would fly all Illuminators into the heart of the enemy fleet and let them loose (presuming they weren't already there).
Malice: propagated damage across the entire enemy fleet. The other things hurt, but this is what made entire fleets pop.
Let's presume for a second that you only had Ruthlessness going for you when you cast this with 50 ships in the enemy fleet. That's 1+(50-1)*0.3=15.7 DPS for ten seconds. That hurt, but was only a part of things.
Let's say you hit five ships with Cleansing Brilliance. That's 2,000+(5-1)*2000=10,000 damage to afflicted units and 8,000 damage to any units that happened to be hit with Malice but not the beam.
When they nerfed Malice, a little piece of me died. It's also the reason that I switched from Advent to Vasari as my primary race and why in Rebalanced Races includes a buff to Malice's target count. That's also the patch that nerfed nano bomb and Missile Barrage. That was my least favorite patch in the history of Sins.