I wanted to try the 1.6 Beta but the game did start and ctd before the starting trailer.
I wen back to 1.5 and noticed the same problem. After trying some things i switched to windows mode and got it to run once, but the games said to me i was running to old drivers. After this i keeps cdt.

I now deinstalled the newest nvidia drivers:

361.75 from 2016.1.27

And did a clean install from the drivers before them: 361.43 from Dec 15

Now everything runs fine, but i think you should perhaps look into it, as some more may run into this problem.
My Specs:

Win 10 64b
16GB RAM
I7 4970k
Nvidia Geforce 980TI

If you like to get more infos, just post here.