Does this happen each time you load that save?

Had a bug which forced me to close the game (somehow managed to move a ship as a popup for colonyship was coming up at the same time - could not populate colonyship, kept coming back up)

Anyway, tried to load the autosave, and immediately CTD.

I had this symptom.  As a workaround/diagnostic, support had me rename the GC3 folder in My Games,  I then ran the program and it rebuilt the folder.  Now, I can my play save game files without problem.  Never did hear what the source of the problem was, so there is no guarantee the workaround will also help you, but it is worth a try.