For anyone else that sees this and wants to "me too".

The more information you can provide the more likely it will be to be able to identify what might be causing the problem and what can be done to resolve it.

Gas Powered Games have a history of driver conflicts with Logitech Webcams, would you have one of those installed per chance?

FYI, my friend and I both have pretty much identical systems, we both use comodo etc.  Windows XP

For some reason I can run the game no problem even with comodo going and he can't.  He disabled the defense and that worked but you shouldn't have to do that.

When he has defense+ enabled, he can actually start the game by spaming the .exe - eventually this gets him in even with comodo.

Neither of us have logitech stuff.

We played supreme commander quite a bit and never had these issues.